By Michael B. M.D. Fossel
Far from purely sharing a typical onset past due within the lifespan, age-related ailments are associated via primary universal features on the genetic and mobile degrees. Emphasizing human phone mechanisms, the 1st part offers and analyzes our present knowledege of telomere biology and phone senescence. In amazing educational aspect, the textual content brings the reader modern on telomere upkeep, telomerase dynamics, and present study on mobilephone senescence--and the final model--cell senescence because the valuable part in human senescence and melanoma. for every human malignancy, the bankruptcy stories and analyzes all on hand facts on telomeres and telomerase, in addition to summarizing present paintings on their medical software in either prognosis and melanoma therapy.
The moment variation, orientated via organs and tissues, explores the particular physiological effect of telephone senescence and getting older on medical disorder. After a precis of the literature on early getting older syndromes--the progerias--the textual content studies getting older ailments (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune getting older, presbyopia, sarcopenia, etc.) within the context of the tissues during which they ensue. all the ten medical chapters--skin, cardiovascular procedure, bone and joints, hematopoetic and immune structures, endocrine, CNS, renal, muscle, GI, and eyes--examines what we all know in their pathology, the function of phone sensescence, and scientific interventions, either present and potential.
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Cells, Aging, and Human Disease by Michael B. M.D. Fossel