Colm Duffy's Heteroaromatic Lipoxin A4 Analogues: Synthesis and PDF

By Colm Duffy

ISBN-10: 3642246311

ISBN-13: 9783642246319

ISBN-10: 364243892X

ISBN-13: 9783642438929

In this thesis Colm Duffy experiences the chemistry and biology of sturdy lipoxin analogues. Colm has ready for the 1st time ever a pyridine-containing LXA4 analogue in enantiomerically natural shape. organic evaluate decided that either epimers on the benzylic place suppress key cytokines recognized to be enthusiastic about inflammatory affliction, with the (R)-epimer proving such a lot efficacious. additionally the writer built an exceptional path to a comparable thiophene-containing analogue that still confirmed fascinating organic task. either routes have encouraged additional paintings in  the synthesis of extra heteroaromatic analogues for organic evaluate.

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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation (Springer Theses) by Colm Duffy


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