By Colm Duffy
ISBN-10: 3642246311
ISBN-13: 9783642246319
ISBN-10: 364243892X
ISBN-13: 9783642438929
In this thesis Colm Duffy experiences the chemistry and biology of sturdy lipoxin analogues. Colm has ready for the 1st time ever a pyridine-containing LXA4 analogue in enantiomerically natural shape. organic evaluate decided that either epimers on the benzylic place suppress key cytokines recognized to be enthusiastic about inflammatory affliction, with the (R)-epimer proving such a lot efficacious. additionally the writer built an exceptional path to a comparable thiophene-containing analogue that still confirmed fascinating organic task. either routes have encouraged additional paintings in the synthesis of extra heteroaromatic analogues for organic evaluate.
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Extra info for Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation (Springer Theses)
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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation (Springer Theses) by Colm Duffy
by Anthony
4.1