Self-Assembling Complexes for Gene Delivery: From Laboratory - download pdf or read online

By Philip L. Felgner,Leonard W. Seymour,Alexander V. Kabanov

ISBN-10: 047197269X

ISBN-13: 9780471972693

fresh years have witnessed an explosion of task within the box of gene treatment. Following advances in our realizing of the molecular foundation of sickness, hopes are excessive that the great capability marketplace for medicinal drugs using antisense nucleotides and genes will someday be fulfilled. besides the fact that, many stumbling blocks stay, now not least difficulties within the expertise of gene supply platforms. a lot of state-of-the-art examine specializes in non-viral techniques to gene supply. Of specific significance are supramolecular complexes shaped among DNA and numerous traditional and artificial polymers and lipids, in a different way often called 'self-assembling complexes for gene delivery'. In view of this truth, the editors of this quantity have assembled a world group of individuals to give updated stories of the main chemical, organic and scientific elements of such gene supply vectors. Reflecting the variety of study during this box, this ebook comprehensively covers:
* the foundations of self-assembly
* usual mechanisms for gene supply to cells
* cationic lipids and liposomes
* polyelectrolyte DNA complexes
* systemic biodistribution of drug supply systems
* concentrating on of conjugates for gene delivery
* new techniques to gene delivery
* scientific evaluation
Self-assembling Complexes for Gene supply is a necessary reference for all pros with an curiosity in gene and antisense remedy or novel drug supply platforms, together with medicinal and pharmaceutical chemists, clinicians, human geneticists, molecular biologists and pharmacologists.

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Self-Assembling Complexes for Gene Delivery: From Laboratory to Clinical Trial by Philip L. Felgner,Leonard W. Seymour,Alexander V. Kabanov


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