By Alex Avdeef
Explains the way to practice and research the result of the most recent physicochemical methods
With this booklet as their advisor, readers have entry to the entire present details had to completely examine and appropriately be sure a compound's pharmaceutical homes and their results on drug absorption. The booklet emphasizes oral absorption, explaining the entire physicochemical equipment used this present day to research drug applicants. furthermore, the writer offers professional assistance to assist readers research the result of their reports with a purpose to choose the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating all of the newest study findings, tools, and assets, including:
Descriptions and purposes of recent PAMPA types, drawing on greater than thirty papers released by means of the author's learn group
Two new chapters interpreting permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded info and strategies to help pKa determination
New examples explaining the remedy of virtually insoluble try compounds
Additional case reviews demonstrating using the newest physicochemical techniques
New, revised, and improved database tables in the course of the book
Well over two hundred drawings support readers larger comprehend tricky recommendations and supply a visible advisor to advanced systems. furthermore, over 800 references function a gateway to the first literature within the box, facilitating extra learn into all of the themes coated within the book.
This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of study. it's also instructed as a supplemental textual content for graduate classes in pharmaceutics.
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Additional info for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef