By Mara Dierssen,Rafael de la Torre Fornell
ISBN-10: 044454299X
ISBN-13: 9780444542991
Down syndrome (DS) is the commonest instance of neurogenetic aneuploid sickness resulting in psychological retardation. as a rule, DS effects from an additional reproduction of chromosome 21 (HSA21) generating deregulated gene expression in mind that offers increase to subnormal highbrow functioning. the subject of this quantity is of wide curiosity for the neuroscience group, since it tackles the concept that of neurogenomics, that's, how the genome as an entire contributes to a neurodevelopmental cognitive issues, similar to DS, and therefore to the improvement, constitution and serve as of the worried approach.
This quantity of development in mind learn discusses comparative genomics, gene expression atlases of the mind, community genetics, engineered mouse versions and purposes to human and mouse behavioral and cognitive phenotypes. It brings jointly scientists of numerous backgrounds, by means of facilitating the mixing of analysis directed at diversified degrees of organic association, and by means of highlighting translational learn and the appliance of the prevailing clinical wisdom to enhance more suitable DS remedies and cures.
- Leading authors assessment the cutting-edge of their box of research and supply their perspectives and views for destiny research
- Chapters are broadly referenced to supply readers with a complete record of assets at the issues covered
- All chapters contain entire historical past details and are written in a transparent shape that also is available to the non-specialist
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Down Syndrome: From Understanding the Neurobiology to Therapy (Progress in Brain Research) by Mara Dierssen,Rafael de la Torre Fornell
by Joseph
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