By Douglas W. DeSimone,Robert Mecham
ISBN-10: 3642359345
ISBN-13: 9783642359347
ISBN-10: 3642427405
ISBN-13: 9783642427404
Cells within the constructing embryo depend upon indications from the extracellular setting to aid consultant their differentiation. a big mediator during this method is the extracellular matrix – secreted macromolecules that engage to shape huge protein networks outdoors the cellphone. in the course of improvement, the extracellular matrix serves to split adjoining telephone teams, participates in constructing morphogenic gradients, and, via its skill to have interaction at once will cell-surface receptors, offers developmental clocks and positional details. This quantity discusses how the extracellular matrix impacts basic developmental strategies and the way version platforms can be utilized to explain ECM functionality. the subjects addressed variety from how ECM affects early improvement in addition to fix methods within the grownup that recapitulate developmental pathways.
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Extracellular Matrix in Development (Biology of Extracellular Matrix) by Douglas W. DeSimone,Robert Mecham
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