Laron Syndrome - From Man to Mouse: Lessons from Clinical by Zvi Laron,J. Kopchick PDF

By Zvi Laron,J. Kopchick

ISBN-10: 3642111823

ISBN-13: 9783642111822

ISBN-10: 3662501716

ISBN-13: 9783662501719

Laron syndrome (LS), or basic progress hormone (GH) insensitivity, was once first defined in 1966. due to the fact then, many sufferers world wide were clinically determined with LS, which includes defects within the GH receptor that reason mixed congenital deficiency of GH and IGF-I actions. during this entire publication the authors draw upon 50 years of multidisciplinary medical and investigative follow-up of the big Israeli cohort of LS sufferers. The genetic foundation of the syndrome is absolutely thought of, and all elements of the pathophysiology of IGF-I deficiency are defined. information derived from the lately generated mouse version of LS are reviewed and in comparison with the human LS event. priceless recommendation is equipped on therapy, and remedy results, corresponding to metabolic results, adipose tissue changes, and effect on getting older, are absolutely explored. jointly, this ebook condenses, consolidates, compares, and contrasts information derived from the human and mouse LS reports and gives a distinct source for medical and easy scientists to judge and examine IGF-I and GH actions.

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Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience by Zvi Laron,J. Kopchick


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