Stefano Mangani's Disruption of Protein-Protein Interfaces: In Search of New PDF

By Stefano Mangani

ISBN-10: 3642379982

ISBN-13: 9783642379987

ISBN-10: 3642433898

ISBN-13: 9783642433894

"Disruption of Protein-Protein Interfaces" reports the most recent advancements and destiny views in drug discovery at protein-protein interfaces. The authors element experimental and computational instruments to take on the topic and spotlight the contribution of the Italian study neighborhood to the sphere. proof indicates that blockading or modulating protein-protein interactions could bring about the improvement of important new medications. as a result, in recent times nice attempt has been devoted to unveiling the molecular information of protein-protein interfaces by way of structural thoughts e.g. X-ray diffraction, NMR spectroscopy. This booklet, written and edited by way of leaders within the box, presents examples from the literature of successes and screw ups to improve drug-like molecules potent in interacting at protein-protein interfaces.

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