Antoine Simonneau's thesis highlights the improvement of recent cycloisomerization reactions in the course of the activation of alkynes with gold complexes. First Simonneau describes 1,6-enynes and their direct conversion into allenes via 1,5-hydride or ester migration techniques. the writer and his staff used acceptable propargylic sensible teams to accomplish this conversion. This examine indicates that O-tethered 1,6-enynes wearing a strained cycloalkane on the propargylic place may well endure a cyclopropanation/ring growth cascade response. the writer hired this rearrangement because the start line within the layout of a brand new macro cycle synthesis. the subsequent a part of the thesis specializes in the cycloisomerization of diynes regarding because the first step of the method the rearrangement of 1 alkyne accomplice into an allene due to a gold-catalyzed 1,3-shift of a propargylic ester. The thesis discloses a brand new cycloisomerization trend that includes a 1,5-carbonyl move, giving upward push to unparalleled cross-conjugated diketones. within the ultimate a part of the examine, Simmoneau investigates the gold-catalyzed cycloisomerization mechanism of 1,6-enynes and questions the intermediacy of gold acetylides. by means of the technique of NMR and mass spectrometry research, theoretical therapy and resolution experiments, it was once attainable to rule out the involvement of those species within the catalytic cycle. This thesis has ended in a few guides in high-impact journals.